Quick answer: Icariin from horny goat weed inhibits the PDE5 enzyme in test tubes and cell studies, but no human trial has tested it for erections. It should not be combined with ED drugs or nitrates without a doctor.
The lab finding
Icariin blocks PDE5, the enzyme ED drugs target, in vitro (Ning 2006).
The gap
A lab effect is not a human effect. Absorption, dose and real-world outcomes are untested.
Safety
Because of the PDE5 action, combining it with nitrates or ED drugs is a question for your doctor. See medications safety.
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General information, not medical advice. HoneyPower is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.